地西泮在口服後，迅速被身體吸收，藥效很快開始，以靜脈注射，藥效更快。地西泮經肝臟代謝，其代謝物經腎臟排泄，只有極少量的地西泮沒有被代謝便排泄。
Diazepam and its metabolites are excreted largely from the urine, predominantly as their glucuronide conjugates. The clearance of diazepam is twenty to thirty mL/min in young Grown ups. Diazepam accumulates on numerous dosing and There is certainly some evidence the terminal elimination 50 %-existence is somewhat extended.
“Altering to existence with epilepsy was hard. At time, there weren’t any fast-use seizure prescription drugs for episodes of Recurrent seizures available to help in an crisis that can be immediately administered by someone close by.
Diazepam and its metabolites are remarkably sure to plasma proteins (diazepam ninety eight%). Diazepam and its metabolites cross the blood-brain and placental obstacles and can also be located in breast milk in concentrations about a person tenth of Individuals in maternal plasma (times 3 to nine write-up-partum).
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har självmordstankar har epilepsi eller tidigare har haft krampanfall har nedsatt lever eller njurfunktion
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Allergic reactions could arise with the 1st dose. You'll want to tell your Health care supplier If you're allergic to any with the substances of diazepam or almost every other benzodiazepines. It is additionally vital to share your clinical record together with your medical doctor as some disorders may well conflict with its use.
Subsequent overdose with oral benzodiazepines, basic supportive steps need to be used such as the monitoring of respiration, pulse, and blood pressure. Vomiting ought to be induced (within 1 hour) Should the affected individual is mindful. Gastric lavage ought to be undertaken Using the airway guarded If your client is unconscious. Intravenous fluids really should be administered. If there isn't any gain in emptying the stomach, activated charcoal ought to be specified to lessen absorption.
Some contraceptive pills can preserve diazepam in your more info body for lengthier and boost its influence. [seven] You may additionally get bleeding concerning your durations if you are taking diazepam and contraceptive supplements jointly, nonetheless it will never halt the capsule from staying productive.
As with other agents which have anticonvulsant activity, when diazepam is applied being an adjunct in managing convulsive Problems, the opportunity of an increase in the frequency and/or severity of grand mal seizures may perhaps demand a rise in the dosage of ordinary anticonvulsant medication.
Inappropriate habits and also other adverse behavioral outcomes are already reported when working with benzodiazepines. Must these manifest, use from the drug must be discontinued. They usually tend to occur in little ones and within the aged.
A reduce dose is suggested for patients with chronic respiratory insufficiency, on account of the risk of respiratory depression.